There exists a release of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors during the dorsal horn to reduce afferent suffering transmission and produce analgesia. Consequently, medicine like clonidine that goal alpha-2 receptors can affect the transmission of pain. For people who get dizzy when standing: https://peterv801aya5.sharebyblog.com/profile