And finally, clonidine improves neuraxial opioids and, together with fentanyl, interacts within an additive manner, which may lessen the dose of every part by 60% for postoperative analgesia. Significant Allergic Reactions. Clonidine might lead to allergic reactions, which may be severe. Cease using clonidine and obtain support without delay https://www.proleviate.com/post/the-new-pain-killer-conolidine